Virtual Screening of the Multi-pathway and Multi-gene Regulatory Molecular Mechanism of Dachengqi Decoction in the Treatment of Stroke Based on Network Pharmacology.

Pei, Lishan; Shen, Xia; Yan, Yonggang; Tan, Conge; Qu, Kai; Zou, Junbo; Wang, Yanxia; Ping, Fan

Pei, Lishan; Shen, Xia; Yan, Yonggang; Tan, Conge; Qu, Kai; Zou, Junbo; Wang, Yanxia; Ping, Fan.

Affiliation

Pei L; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Shen X; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Yan Y; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Tan C; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Qu K; Department of Nephrology, Shaanxi Hospital of Chinese Medicine, Xi'an 710003, China.
Zou J; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Wang Y; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Ping F; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.

Comb Chem High Throughput Screen ; 23(8): 775-787, 2020.

Article in En | MEDLINE | ID: mdl-32160845

Subject(s)

Computational Biology/methods; Models, Molecular; Plant Extracts/chemistry; Stroke/drug therapy; Apoptosis/drug effects; Blood Platelets/drug effects; Blood Platelets/metabolism; Blood Pressure/drug effects; Databases, Chemical; Gene Expression Regulation/drug effects; Gene Ontology; Humans; Inflammation/drug therapy; Lipid Metabolism/drug effects; Medicine, Chinese Traditional; Mitogen-Activated Protein Kinase Kinases/metabolism; Oxidative Stress/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Plant Extracts/administration & dosage; Plant Extracts/pharmacokinetics; Signal Transduction; Vascular Endothelial Growth Factor A/metabolism

Key words

ADME; Dachengqi decoction; GEO verified; bidirectional regulation; molecular mechanism; stroke

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Plant Extracts / Models, Molecular / Computational Biology / Stroke Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Comb Chem High Throughput Screen Year: 2020 Type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google