The effect of total lignans from Fructus Arctii on Streptozotocin-induced diabetic retinopathy in Wistar rats.

Zhang, Huating; Gao, Yingying; Zhang, Jingyun; Wang, Kai; Jin, Tong; Wang, Haiying; Ruan, Kefeng; Wu, Fei; Xu, Zhaohui

Zhang, Huating; Gao, Yingying; Zhang, Jingyun; Wang, Kai; Jin, Tong; Wang, Haiying; Ruan, Kefeng; Wu, Fei; Xu, Zhaohui.

Affiliation

Zhang H; Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Gao Y; Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zhang J; Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wang K; Center for Drug Safety Evaluation, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Jin T; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wang H; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Ruan K; Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wu F; Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xu Z; Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: lntcmx@163.com.

J Ethnopharmacol ; 255: 112773, 2020 Jun 12.

Article in En | MEDLINE | ID: mdl-32199990

Subject(s)

Arctium; Diabetes Mellitus, Experimental/drug therapy; Diabetic Retinopathy/prevention & control; Fruit; Lignans/pharmacology; Plant Extracts/pharmacology; Retina/drug effects; Animals; Apoptosis/drug effects; Arctium/chemistry; Blood Glucose/drug effects; Blood Glucose/metabolism; Blood-Retinal Barrier/drug effects; Blood-Retinal Barrier/metabolism; Blood-Retinal Barrier/pathology; Diabetes Mellitus, Experimental/chemically induced; Diabetes Mellitus, Experimental/metabolism; Diabetic Retinopathy/etiology; Diabetic Retinopathy/metabolism; Diabetic Retinopathy/pathology; Enzyme Activation; Fruit/chemistry; Lignans/isolation & purification; Male; Plant Extracts/isolation & purification; Protein Kinase C beta/genetics; Protein Kinase C beta/metabolism; Rats, Wistar; Retina/metabolism; Retina/pathology; Retinal Ganglion Cells/drug effects; Retinal Ganglion Cells/metabolism; Retinal Ganglion Cells/pathology; Signal Transduction; Streptozocin; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

Key words

Blood-retina barrier; Diabetic retinopathy; Fructus Arctii; PKC ß; VEGF

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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Retina / Plant Extracts / Lignans / Arctium / Diabetes Mellitus, Experimental / Diabetic Retinopathy / Fruit Type of study: Etiology_studies / Prognostic_studies Language: En Journal: J Ethnopharmacol Year: 2020 Type: Article Affiliation country: China

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