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Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A.
Morais, Thiago R; Conserva, Geanne A Alves; Varela, Marina T; Costa-Silva, Thais A; Thevenard, Fernanda; Ponci, Vitor; Fortuna, Ana; Falcão, Amílcar C; Tempone, Andre G; Fernandes, João Paulo S; Lago, João Henrique G.
Affiliation
  • Morais TR; Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo, São Paulo, 09972-270, Brazil.
  • Conserva GAA; Center of Natural Sciences and Humanities, Universidade Federal do ABC, São Paulo, 09210-580, Brazil.
  • Varela MT; Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo, São Paulo, 09972-270, Brazil.
  • Costa-Silva TA; Center of Natural Sciences and Humanities, Universidade Federal do ABC, São Paulo, 09210-580, Brazil.
  • Thevenard F; Center of Natural Sciences and Humanities, Universidade Federal do ABC, São Paulo, 09210-580, Brazil.
  • Ponci V; Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo, São Paulo, 09972-270, Brazil.
  • Fortuna A; Laboratory of Pharmacology, Faculty of Pharmacy of University of Coimbra, 3000-370, Coimbra, Portugal.
  • Falcão AC; CIBIT/ICNAS - Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, 3000-370, Coimbra, Portugal.
  • Tempone AG; Laboratory of Pharmacology, Faculty of Pharmacy of University of Coimbra, 3000-370, Coimbra, Portugal.
  • Fernandes JPS; CIBIT/ICNAS - Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, 3000-370, Coimbra, Portugal.
  • Lago JHG; Centre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo, 01246-000, Brazil.
Sci Rep ; 10(1): 5467, 2020 03 25.
Article in En | MEDLINE | ID: mdl-32214193
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Trypanocidal Agents / Trypanosoma cruzi / Biological Products / Chagas Disease / Lignans / Plant Leaves / Lauraceae / Antiparasitic Agents Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: Brazil
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Trypanocidal Agents / Trypanosoma cruzi / Biological Products / Chagas Disease / Lignans / Plant Leaves / Lauraceae / Antiparasitic Agents Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: Brazil