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Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.
Ciammaichella, Alina; Ferrigno, Federica; Basta, Andreina; D'Amico, Melania; Biancofiore, Ilaria; Nardi, Valentina; Ponzi, Simona; Graziani, Rita; Gennari, Nadia; Vittoria Orsale, Maria; Fini, Ivan; Paonessa, Giacomo; Summa, Vincenzo; Harper, Steven; Ontoria, Jesus M.
Affiliation
  • Ciammaichella A; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy. Electronic address: a.ciammaichella@irbm.com.
  • Ferrigno F; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Basta A; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • D'Amico M; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Biancofiore I; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Nardi V; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Ponzi S; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Graziani R; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Gennari N; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Vittoria Orsale M; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Fini I; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Paonessa G; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Summa V; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Harper S; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
  • Ontoria JM; Departments of Chemistry and Biology, IRBM S.p.A, Via Pontina km 30,600, 00071 Pomezia, Rome, Italy.
Bioorg Med Chem Lett ; 30(12): 127207, 2020 06 15.
Article in En | MEDLINE | ID: mdl-32354566
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Trypanocidal Agents / Trypanosoma brucei brucei / Trypanosomiasis, African / Growth Inhibitors Language: En Journal: Bioorg Med Chem Lett Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Trypanocidal Agents / Trypanosoma brucei brucei / Trypanosomiasis, African / Growth Inhibitors Language: En Journal: Bioorg Med Chem Lett Year: 2020 Type: Article