A Computational Approach to Investigate the HDAC6 and HDAC10 Binding Propensity of Psidium guajava-derived Compounds as Potential Anticancer Agents.

Adewole, Kayode Ezekiel; Ishola, Ahmed Adebayo

Adewole, Kayode Ezekiel; Ishola, Ahmed Adebayo.

Affiliation

Adewole KE; Department of Biochemistry, Faculty of Basic Medical Sciences, University of Medical Sciences Ondo City, Ondo State, Nigeria.
Ishola AA; Central Research Laboratories Limited, 132B University Road Ilorin, Kwara State, Nigeria.

Curr Drug Discov Technol ; 18(3): 423-436, 2021.

Article in En | MEDLINE | ID: mdl-32357815

Subject(s)

Histone Deacetylase 6/metabolism; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylases/metabolism; Neoplasms/drug therapy; Plant Extracts/pharmacology; Psidium/chemistry; Catalytic Domain/drug effects; Catalytic Domain/genetics; Drug Discovery/methods; Histone Deacetylase 6/antagonists & inhibitors; Histone Deacetylase 6/genetics; Histone Deacetylase Inhibitors/therapeutic use; Histone Deacetylases/genetics; Humans; Molecular Docking Simulation; Plant Extracts/chemistry; Plant Extracts/therapeutic use; Protein Binding/genetics; Sequence Homology, Amino Acid

Key words

ADME web tool; Binding affinity; Epigenetic modification; Histone deacetylase; Histone deacetylase inhibitor; Psidium guajava

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Full text: 1 Database: MEDLINE Main subject: Plant Extracts / Psidium / Histone Deacetylase Inhibitors / Histone Deacetylase 6 / Histone Deacetylases / Neoplasms Type of study: Prognostic_studies Language: En Journal: Curr Drug Discov Technol Year: 2021 Type: Article Affiliation country: Nigeria

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