Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress.

Wu, Xiao-Li; Deng, Min-Zhen; Gao, Zhi-Jie; Dang, Yuan-Ye; Li, Yu-Cui; Li, Chu-Wen

Wu, Xiao-Li; Deng, Min-Zhen; Gao, Zhi-Jie; Dang, Yuan-Ye; Li, Yu-Cui; Li, Chu-Wen.

Affiliation

Wu XL; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Deng MZ; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Gao ZJ; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Dang YY; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Li YC; Mathematical Engineering Academy of Chinese Medicine, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address: liyucui@gzucm.edu.cn.
Li CW; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. Electronic

Int Immunopharmacol ; 84: 106559, 2020 Jul.

Article in En | MEDLINE | ID: mdl-32402951

Subject(s)

Benzylisoquinolines/therapeutic use; Cognitive Dysfunction/drug therapy; Diabetes Mellitus, Experimental/drug therapy; Memory Disorders/drug therapy; Neuroprotective Agents/therapeutic use; Animals; Benzylisoquinolines/pharmacology; Cognitive Dysfunction/metabolism; Cytokines/metabolism; Diabetes Mellitus, Experimental/metabolism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress/drug effects; Female; Hippocampus/drug effects; Hippocampus/metabolism; Inflammasomes/metabolism; Lipid Metabolism/drug effects; Memory/drug effects; Memory Disorders/metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Neuroprotective Agents/pharmacology; Spatial Learning/drug effects

Key words

Cognitive and memory dysfunction; Diabetes mellitus; ER stress; NLRP3 inflammasome; Neferine

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Full text: 1 Database: MEDLINE Main subject: Neuroprotective Agents / Benzylisoquinolines / Diabetes Mellitus, Experimental / Cognitive Dysfunction / Memory Disorders Type of study: Prognostic_studies Language: En Journal: Int Immunopharmacol Year: 2020 Type: Article Affiliation country: China

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