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Potential Applications of 68Ga-PSMA-11 PET/CT in the Evaluation of Salivary Gland Uptake Function: Preliminary Observations and Comparison with 99mTcO4 - Salivary Gland Scintigraphy.
Zhao, Yanhong; Xia, Yuxiao; Liu, Huipan; Wang, Zi; Chen, Yue; Zhang, Wei.
Affiliation
  • Zhao Y; Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Xia Y; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, No. 25, Taiping St., Luzhou, Sichuan 646000, China.
  • Liu H; Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Wang Z; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, No. 25, Taiping St., Luzhou, Sichuan 646000, China.
  • Chen Y; Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Zhang W; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, No. 25, Taiping St., Luzhou, Sichuan 646000, China.
Contrast Media Mol Imaging ; 2020: 1097516, 2020.
Article in En | MEDLINE | ID: mdl-32410918
Purpose: To preliminarily evaluate the feasibility and potential of using 68Ga-PSMA-11 PET/CT in evaluating the function of salivary glands and lacrimal glands in comparison with 99mTc-pertechnetate (99mTcO4 -) salivary gland scintigraphy (SGS). Methods: A retrospective study was performed in 15 patients with different degrees of xerostomia and suspected salivary gland dysfunction. Each patient underwent 68Ga-PSMA-11 PET/CT first and SGS the next day, and the findings of both scans were compared. Results: The results of 68Ga-PSMA-11 PET/CT and SGS were consistent in 12/15 patients (80%) and were inconsistent in the remaining patients (20%). For 5 (33.3%) of 15 patients, 68Ga-PSMA-11 PET/CT provided more information than did SGS. Additionally, 68Ga-PSMA-11 PET/CT corrected the misdiagnosis by SGS for 1 patient. Conclusions: 68Ga-PSMA-11 PET/CT is a potentially useful imaging tool for evaluating the function of salivary glands and lacrimal glands. 68Ga-PSMA-11 PET/CT can be a promising supplement to SGS, and its clinical value deserves further study.
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Full text: 1 Database: MEDLINE Main subject: Oligopeptides / Salivary Glands / Radionuclide Imaging / Edetic Acid / Sodium Pertechnetate Tc 99m / Positron Emission Tomography Computed Tomography Language: En Journal: Contrast Media Mol Imaging Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Oligopeptides / Salivary Glands / Radionuclide Imaging / Edetic Acid / Sodium Pertechnetate Tc 99m / Positron Emission Tomography Computed Tomography Language: En Journal: Contrast Media Mol Imaging Year: 2020 Type: Article Affiliation country: China