Dual X-ray absorptiometry has limited utility in detecting bone pathology in children with hypophosphatasia: A pooled post hoc analysis of asfotase alfa clinical trial data.

Simmons, Jill H; Rush, Eric T; Petryk, Anna; Zhou, Shanggen; Martos-Moreno, Gabriel Á

Simmons, Jill H; Rush, Eric T; Petryk, Anna; Zhou, Shanggen; Martos-Moreno, Gabriel Á.

Affiliation

Simmons JH; Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Village at Vanderbilt, 1500 21st Ave South, Suite 1514, Nashville, TN 37212, USA. Electronic address: jill.h.simmons@vumc.org.
Rush ET; Department of Pediatrics, Children's Mercy Kansas City, Adele Hall Campus, 2401 Gillham Rd, Kansas City, MO 64108, USA; University of Missouri - Kansas City School of Medicine, 2411 Holmes St, Kansas City, MO 64108, USA; University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS 661
Petryk A; Alexion Pharmaceuticals, Inc., 121 Seaport Blvd., Boston, MA 02210, USA. Electronic address: Anna.Petryk@alexion.com.
Zhou S; Clinical Development Services-Corporate, Covance, Inc., 210 Carnegie Center, Princeton, NJ 08540, USA. Electronic address: shanggen.zhou@covance.com.
Martos-Moreno GÁ; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, IIS La Princesa, Av. de Menéndez Pelayo, 65, 28009 Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Calle Arzobispo Morcillo, 4, 28029 Madrid, Spain; CIBERobn, Instituto de Salud Carlos III, C/ Sinesio D

Bone ; 137: 115413, 2020 08.

Article in En | MEDLINE | ID: mdl-32417537

Subject(s)

Hypophosphatasia; Absorptiometry, Photon; Alkaline Phosphatase; Bone Density; Child; Humans; Hypophosphatasia/diagnostic imaging; Hypophosphatasia/drug therapy; Immunoglobulin G; Male; Recombinant Fusion Proteins

Key words

Bone mineral content; Bone mineral density; Metabolic bone disease; Tissue-nonspecific alkaline phosphatase

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google