Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit.
J Asian Nat Prod Res
; 23(5): 466-477, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-32447972
ABSTRACT
Diosgenin (DI) and trigonelline (TRG) are the main bioactive compounds of fenugreek seed. A micro-extraction method using magnetic nanocomposites coupled with ion-pairing reversed phase HPLC (RP-HPLC) method was used to determine the analytes in rabbit plasma. The main PK parameters after oral administration of pure DI and the extract were Cmax 0.48, 0.057 µg/ml; tmax 1, 2 h; and t1/2ß 6.23, 15.04 h, respectively. Pure TRG and the extract PK parameters were Cmax 0.121, 0.081 µg/ml; tmax 1.30, 1.30 h; and t1/2ß 20.06, 24.70 h, respectively. Generally, the PK profile of the two compounds was best fitted on the two-compartment model.[Formula see text].
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Trigonella
/
Diosgenin
Language:
En
Journal:
J Asian Nat Prod Res
Year:
2021
Type:
Article
Affiliation country:
Iran