Cinnamolide sesquiterpene lactone suppresses in vitro and in vivo cancer cell growth in cisplatin-resistant human cervical carcinoma cells by inducing mitochondrial mediated apoptosis, caspase activation, loss of MMP and targeting Akt/ß-Catenin signaling pathway.

Hou, Jing; Kan, Changli; Zhu, Yanju; Zhang, Yi; Zhou, Bingfeng; Ren, Chunli; Fu, Jiuyuan; Guo, Yanwei; Zhang, Jinhuan

Hou, Jing; Kan, Changli; Zhu, Yanju; Zhang, Yi; Zhou, Bingfeng; Ren, Chunli; Fu, Jiuyuan; Guo, Yanwei; Zhang, Jinhuan.

Affiliation

Hou J; Department of Obstetrics, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China.

J BUON ; 25(2): 709-715, 2020.

Article in En | MEDLINE | ID: mdl-32521857

Subject(s)

Lactones/therapeutic use; Membrane Potential, Mitochondrial/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Sesquiterpenes/therapeutic use; Uterine Cervical Neoplasms/drug therapy; beta Catenin/metabolism; Apoptosis; Cell Proliferation; Female; HeLa Cells; Humans; Lactones/pharmacology; Sesquiterpenes/pharmacology; Signal Transduction; Uterine Cervical Neoplasms/genetics

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Sesquiterpenes / Uterine Cervical Neoplasms / Proto-Oncogene Proteins c-akt / Beta Catenin / Membrane Potential, Mitochondrial / Lactones Language: En Journal: J BUON Year: 2020 Type: Article Affiliation country: China

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