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Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae).
Waleguele, Christine C; Mba'ning, Brice M; Awantu, Angelbert F; Bankeu, Jean J K; Fongang, Yannick S F; Ngouela, Augustin S; Tsamo, Etienne; Sewald, Norbert; Lenta, Bruno N; Krause, Rui W M.
Affiliation
  • Waleguele CC; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Mba'ning BM; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Awantu AF; Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39 Bambili, Cameroon.
  • Bankeu JJK; Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39 Bambili, Cameroon.
  • Fongang YSF; Department of Chemistry, Higher Teacher Training College, The University of Maroua, P.O. Box 55 Maroua, Cameroon.
  • Ngouela AS; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Tsamo E; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon.
  • Sewald N; Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.
  • Lenta BN; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon.
  • Krause RWM; Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
Molecules ; 25(12)2020 Jun 21.
Article in En | MEDLINE | ID: mdl-32575860
ABSTRACT
The MeOH/CH2Cl2 (11) extracts of the roots and leaves of Beilschmiedia louisii and B. obscura showed potent antitrypanosomal activity during preliminary screening on Trypanosoma brucei brucei. Phytochemical investigation of these extracts led to the isolation of a mixture of two new endiandric acid derivatives beilschmiedol B (1) and beilschmiedol C (2), and one new phenylalkene obscurene A (3) together with twelve known compounds (4-15). In addition, four new derivatives (11a-11d) were synthesized from compound 11. Their structures were elucidated based on their NMR and MS data. Compounds 5, 6, and 7 were isolated for the first time from the Beilschmiedia genus. Additionally, the NMR data of compound 4 are given here for the first time. The isolates were evaluated for their antitrypanosomal and antimalarial activities against Tb brucei and the Plasmodium falciparum chloroquine-resistant strain Pf3D7 in vitro, respectively. From the tested compounds, the mixture of new compounds 1 and 2 exhibited the most potent antitrypanosomal activity in vitro with IC50 value of 4.91 µM.
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Full text: 1 Database: MEDLINE Main subject: Carboxylic Acids / Plant Extracts / Lauraceae / Anti-Infective Agents / Antimalarials / Antiparasitic Agents Language: En Journal: Molecules Year: 2020 Type: Article Affiliation country: Cameroon
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Full text: 1 Database: MEDLINE Main subject: Carboxylic Acids / Plant Extracts / Lauraceae / Anti-Infective Agents / Antimalarials / Antiparasitic Agents Language: En Journal: Molecules Year: 2020 Type: Article Affiliation country: Cameroon