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Hangover and fatigue: effects of Robuvit® supplementation. A pilot registry study.
Hu, Shu; Belcaro, Gianni; Cesarone, Maria R; Scipione, Claudia; Scipione, Valeria; Hosoi, Morio; Cornelli, Umberto; Pellegrini, Luciano; Dugall, Mark; Feragalli, Beatrice; Cotellese, Roberto.
Affiliation
  • Hu S; Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy.
  • Belcaro G; International Agency for Pharma-Standard Supplements (IA-PSS), Pescara, Italy.
  • Cesarone MR; Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy - cardres@abol.it.
  • Scipione C; International Agency for Pharma-Standard Supplements (IA-PSS), Pescara, Italy.
  • Scipione V; Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy.
  • Hosoi M; International Agency for Pharma-Standard Supplements (IA-PSS), Pescara, Italy.
  • Cornelli U; Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy.
  • Pellegrini L; International Agency for Pharma-Standard Supplements (IA-PSS), Pescara, Italy.
  • Dugall M; Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy.
  • Feragalli B; International Agency for Pharma-Standard Supplements (IA-PSS), Pescara, Italy.
  • Cotellese R; Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy.
Minerva Cardioangiol ; 68(3): 203-208, 2020 Jun.
Article in En | MEDLINE | ID: mdl-32586071
BACKGROUND: The aim of this open registry study was to evaluate the effects of Robuvit® in subjects with hangover after acute alcohol consumption also measuring changes in levels of oxidative stress. A group using standard management (SM) and a group using SM and Robuvit® 300 mg/day for 3 days were compared. METHODS: Nineteen male subjects with hangover were included in the SM group and 22 in the Robuvit® + SM group. RESULTS: The groups were comparable at baseline. No side effects were observed. Fatigue scores - as the main observable symptom in these subjects, in both groups - were significantly lower in the group using Robuvit® (P<0.05) than in the control group after 24 hours. The scores of other symptoms like weakness, thirst, headache, muscle aches and body pain were significantly lower at 24 hours (P<0.05) with the supplement than in the control group. The scores of residual gastrointestinal symptoms (nausea, vomiting and stomach pain) were also significantly lower at 24 hours with Robuvit® (P<0.05). Sleep and rest were significantly better with Robuvit® (P<0.05). Sensory symptoms and cognitive functions were also significantly better with supplementation in comparison with SM only (P<0.05). Finally, scores of mood, concentration, depression, anxiety, irritability were significantly lower (P<0.05) with Robuvit® though these symptoms need a more specific and complete evaluation. Signs of sympathetic activity, tremor, sweating, increased heart rate improved significantly better with the supplement at 24 hours (P<0.05). Oxidative stress was increased at inclusion in all subjects; in the Robuvit® group, oxidative stress decreased significantly (P<0.05) at 24 hours; in controls (SM) oxidative stress showed minimal changes at 24 hours and it remained elevated above normal values (>330 CU). Most symptoms almost disappeared at 24 hours in the Robuvit® group. Significant symptoms were still observed in 11 out of 19 subjects in the SM group in comparison with four of 22 subjects using the supplementation with Robuvit® (P<0.05). Blood tests were normal in all subjects (hematocrit and kidney and liver functional test at 24 hours). CONCLUSIONS: In conclusion, Robuvit® supplementation appears to improve hangover and relieved symptoms faster. More studies are needed to confirm this association between acute alcohol consumption and a possible hepatic dysfunction.
Subject(s)

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Plant Extracts / Oxidative Stress / Hydrolyzable Tannins / Alcoholic Intoxication / Fatigue Language: En Journal: Minerva Cardioangiol Year: 2020 Type: Article Affiliation country: Italy

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Plant Extracts / Oxidative Stress / Hydrolyzable Tannins / Alcoholic Intoxication / Fatigue Language: En Journal: Minerva Cardioangiol Year: 2020 Type: Article Affiliation country: Italy