A Mixture Containing Fermented Achyranthes japonica Nakai Ameliorates Osteoarthritis in Knee Joints of Monoiodoacetate-Injected Rats.
J Med Food
; 23(8): 811-817, 2020 Aug.
Article
in En
| MEDLINE
| ID: mdl-32614635
ABSTRACT
We demonstrated the effect of a mixture containing fermented Achyranthes japonica Nakai (FS) in the context of a monosodium iodoacetate (MIA)-induced osteoarthritis animal model. The mineralization, anabolic and catabolic factors, and the amount of cytokines within the articular cartilage of rats were measured after administration of MIA. We found that dietary supplementation with methylsulfonylmethane (positive control) and FS (FS 100 mg/kg body weight [b.w.] and FS 300 mg/kg b.w.) effectively suppressed pathological changes in the knee joint and inhibited changes in the architectural and mineralization parameters. In addition, prostaglandin E2 (PGE2) and proinflammatory cytokines in the serum and catabolic factors, including matrix metalloproteinase (MMP)-3 and MMP-7 in articular cartilage, were decreased by dietary supplementation with FS in MIA-induced osteoarthritis. Based on these findings, we suggest that FS can be used for the development of potential therapies for osteoarthritis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cartilage, Articular
/
Dietary Supplements
/
Osteoarthritis, Knee
/
Achyranthes
/
Fermented Foods
Type of study:
Prognostic_studies
Language:
En
Journal:
J Med Food
Year:
2020
Type:
Article