Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats.

Li, Qingsong; Zhang, Xi

Li, Qingsong; Zhang, Xi.

Affiliation

Li Q; Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zhang X; Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Synapse ; 75(1): e22181, 2021 01.

Article in En | MEDLINE | ID: mdl-32639628

Subject(s)

Apoptosis/drug effects; Cognitive Dysfunction/chemically induced; Cognitive Dysfunction/drug therapy; Genistein/therapeutic use; Hippocampus/drug effects; Ketamine/toxicity; Animals; Animals, Newborn; Apoptosis/physiology; Cognitive Dysfunction/pathology; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists/toxicity; Fear/drug effects; Fear/physiology; Genistein/pharmacology; Hippocampus/pathology; Male; Maze Learning/drug effects; Maze Learning/physiology; Neuroprotective Agents/pharmacology; Neuroprotective Agents/therapeutic use; Phytoestrogens/pharmacology; Phytoestrogens/therapeutic use; Rats; Rats, Sprague-Dawley

Key words

Akt; GSK-3ß; apoptosis; cognitive impairment; genistein; ketamine

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Full text: 1 Database: MEDLINE Main subject: Apoptosis / Genistein / Cognitive Dysfunction / Hippocampus / Ketamine Language: En Journal: Synapse Year: 2021 Type: Article Affiliation country: China

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