Structure elucidation and NMR assignment of two new hydroxywilfordate-type alkaloids from the stems of Tripterygium hypoglaucum and activity evaluation.

Lu, Li-He; Wu, De-Song; Zha, Yu-Feng; Mei, Shuang-Xi; Li, Xiao-Hui

Lu, Li-He; Wu, De-Song; Zha, Yu-Feng; Mei, Shuang-Xi; Li, Xiao-Hui.

Affiliation

Lu LH; Yunnan Institute of Materia Medica, Kunming, 650111, China.
Wu DS; Innovation and R&D Center, Yunnan Bai Yao Group, Kunming, 650111, China.
Zha YF; Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming, 650111, China.
Mei SX; Yunnan Institute of Materia Medica, Kunming, 650111, China.
Li XH; Innovation and R&D Center, Yunnan Bai Yao Group, Kunming, 650111, China.

Magn Reson Chem ; 58(10): 969-974, 2020 10.

Article in En | MEDLINE | ID: mdl-32643204

Subject(s)

Alkaloids/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Drugs, Chinese Herbal/pharmacology; Hydroxybutyrates/pharmacology; Niacin/analogs & derivatives; Tripterygium/chemistry; Alkaloids/chemistry; Alkaloids/isolation & purification; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic/chemistry; Antineoplastic Agents, Phytogenic/isolation & purification; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal/chemistry; Drugs, Chinese Herbal/isolation & purification; Hydroxybutyrates/chemistry; Hydroxybutyrates/isolation & purification; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Niacin/chemistry; Niacin/isolation & purification; Niacin/pharmacology; RAW 264.7 Cells

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Drugs, Chinese Herbal / Tripterygium / Alkaloids / Hydroxybutyrates / Niacin / Antineoplastic Agents, Phytogenic Language: En Journal: Magn Reson Chem Year: 2020 Type: Article Affiliation country: China

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