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Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1ß, TNF-α, GAP, NGF and ERK involvement.
Araújo-Filho, Heitor G; Pereira, Erik W M; Heimfarth, Luana; Souza Monteiro, Brenda; Santos Passos, Fabiolla Rocha; Siqueira-Lima, Pollyana; Gandhi, Sathiyabama R; Viana Dos Santos, Márcio Roberto; Guedes da Silva Almeida, Jackson Roberto; Picot, Laurent; Grougnet, Raphaël; Almeida, Ray S; Douglas Melo Coutinho, Henrique; Quintans-Júnior, Lucindo J; Martins, Natália; Quintans, Jullyana S S.
Affiliation
  • Araújo-Filho HG; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Pereira EWM; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Heimfarth L; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Souza Monteiro B; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Santos Passos FR; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Siqueira-Lima P; Franco-Brazilian Network on Natural Products (FB2NP), Brazil; College of Science and Technology, Feira de Santana, BA 44000-000, Brazil.
  • Gandhi SR; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Viana Dos Santos MR; Franco-Brazilian Network on Natural Products (FB2NP), Brazil; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil.
  • Guedes da Silva Almeida JR; Franco-Brazilian Network on Natural Products (FB2NP), Brazil; Colegiado de Farmácia, Universidade Federal do Vale do São Francisco, Petrolina, PE 56304-917, Brazil.
  • Picot L; Franco-Brazilian Network on Natural Products (FB2NP), Brazil; La Rochelle Université, UMRi CNRS 7266 LIENSs, 17042 La Rochelle, France.
  • Grougnet R; Franco-Brazilian Network on Natural Products (FB2NP), Brazil; UMR CNRS 8038, Faculty of Pharmacy, University of Paris, France.
  • Almeida RS; Department of Biological Chemistry, Regional University of Cariri, Crato, CE 63105-000, Brazil.
  • Douglas Melo Coutinho H; Department of Biological Chemistry, Regional University of Cariri, Crato, CE 63105-000, Brazil.
  • Quintans-Júnior LJ; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil.
  • Martins N; Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Institute for Research and Innovation in Health, Rua Alfredo Allen, 4200-135 Porto, Portugal. Electronic address: ncmartins@med.up.pt.
  • Quintans JSS; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil. Electronic address: jullyanaquintans@gmail.com.
Int Immunopharmacol ; 86: 106766, 2020 Sep.
Article in En | MEDLINE | ID: mdl-32652504
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Monoterpenes / Peripheral Nerve Injuries / Food Additives / Limonene / Anti-Inflammatory Agents / Motor Neurons / Neuralgia Type of study: Prognostic_studies Language: En Journal: Int Immunopharmacol Year: 2020 Type: Article Affiliation country: Brazil
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Monoterpenes / Peripheral Nerve Injuries / Food Additives / Limonene / Anti-Inflammatory Agents / Motor Neurons / Neuralgia Type of study: Prognostic_studies Language: En Journal: Int Immunopharmacol Year: 2020 Type: Article Affiliation country: Brazil