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Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
Taviano, Maria Fernanda; Miceli, Natalizia; Acquaviva, Rosaria; Malfa, Giuseppe Antonio; Ragusa, Salvatore; Giordano, Deborah; Cásedas, Guillermo; Les, Francisco; López, Víctor.
Affiliation
  • Taviano MF; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Polo Annunziata, University of Messina, 98168 Messina, Italy.
  • Miceli N; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Polo Annunziata, University of Messina, 98168 Messina, Italy.
  • Acquaviva R; Department of Drug Science, Biochemistry Section, University of Catania, 95123 Catania, Italy.
  • Malfa GA; Department of Drug Science, Biochemistry Section, University of Catania, 95123 Catania, Italy.
  • Ragusa S; Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  • Giordano D; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Polo Annunziata, University of Messina, 98168 Messina, Italy.
  • Cásedas G; Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de Gállego (Zaragoza), Spain.
  • Les F; Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de Gállego (Zaragoza), Spain.
  • López V; Instituto Agroalimentario de Aragón-IA2, CITA-Universidad de Zaragoza, 50013 Zaragoza, Spain.
Biology (Basel) ; 9(7)2020 Jul 13.
Article in En | MEDLINE | ID: mdl-32668697
Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts of this species has been evaluated in different bioassays in order to detect potential pharmacological applications. The cytotoxic capacity against the human colorectal adenocarcinoma (CaCo-2) and breast cancer (MCF-7) cell lines was tested using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The extract was investigated as a neuroprotective inhibitor of central nervous system (CNS) enzymes such as monoamine oxidase A, tyrosinase, acetylcholinesterase, and as a natural enzyme inhibitor of α-glucosidase and lipase involved in some metabolic disorders such as obesity or type 2 diabetes. The antioxidant ability was also evaluated in an enzymatic system (xanthine/xanthine oxidase assay). Results showed that the M. incana extract displayed moderate to low cytotoxicity vs. CaCo-2 cells. The extract acted as a superoxide radical scavenger and enzymatic inhibitor of monoamine oxidase A, tyrosinase, α-glucosidase, and lipase. The best results were found in the α-glucosidase assay, as M. incana hydroalcoholic extract was able to inhibit the enzyme α-glucosidase up to 100% without significant differences, compared to the antidiabetic drug acarbose. Matthiola incana has been demonstrated to exert different biological properties. These are important in order to consider this species as a source of bioactive compounds.
Key words

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Language: En Journal: Biology (Basel) Year: 2020 Type: Article Affiliation country: Italy

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Language: En Journal: Biology (Basel) Year: 2020 Type: Article Affiliation country: Italy