Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice.

Wang, Haixia; Jiang, Ning; Lv, Jingwei; Huang, Hong; Liu, Xinmin

Wang, Haixia; Jiang, Ning; Lv, Jingwei; Huang, Hong; Liu, Xinmin.

Affiliation

Wang H; Research Center of Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Jiang N; Research Center of Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Lv J; Research Center of Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Huang H; Research Center of Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Liu X; Research Center of Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. Electronic address: xmliu@implad.ac.cn.

Life Sci ; 258: 118107, 2020 Oct 01.

Article in En | MEDLINE | ID: mdl-32682919

Subject(s)

Brain-Derived Neurotrophic Factor/metabolism; Cognitive Dysfunction/drug therapy; Cognitive Dysfunction/metabolism; Cyclic AMP Response Element-Binding Protein/metabolism; Ginsenosides/therapeutic use; Restraint, Physical; Signal Transduction; Stress, Psychological/drug therapy; Animals; Chronic Disease; Cognitive Dysfunction/blood; Cognitive Dysfunction/physiopathology; Disease Models, Animal; Ginsenosides/chemistry; Ginsenosides/pharmacology; Hippocampus/drug effects; Hippocampus/enzymology; Hippocampus/pathology; Hippocampus/physiopathology; Inflammation/blood; Male; Maze Learning/drug effects; Memory, Short-Term/drug effects; Mice, Inbred C57BL; Models, Biological; Motor Activity/drug effects; Oxidative Stress/drug effects; Receptor, trkB/metabolism; Signal Transduction/drug effects; Stress, Psychological/blood; Stress, Psychological/physiopathology

Key words

Chronic restraint stress; Ginsenoside Rd; Hippocampus; Learning and memory

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Stress, Psychological / Restraint, Physical / Signal Transduction / Cyclic AMP Response Element-Binding Protein / Brain-Derived Neurotrophic Factor / Ginsenosides / Cognitive Dysfunction Type of study: Prognostic_studies Language: En Journal: Life Sci Year: 2020 Type: Article Affiliation country: China

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