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Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Maculins, Timurs; Garcia-Pardo, Javier; Skenderovic, Anamarija; Gebel, Jakob; Putyrski, Mateusz; Vorobyov, Andrew; Busse, Philipp; Varga, Gabor; Kuzikov, Maria; Zaliani, Andrea; Rahighi, Simin; Schaeffer, Veronique; Parnham, Michael J; Sidhu, Sachdev S; Ernst, Andreas; Dötsch, Volker; Akutsu, Masato; Dikic, Ivan.
Affiliation
  • Maculins T; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address: maculins.timurs@gene.com.
  • Garcia-Pardo J; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences,
  • Skenderovic A; Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany.
  • Gebel J; Institute of Biophysical Chemistry & Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main, Germany.
  • Putyrski M; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
  • Vorobyov A; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
  • Busse P; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany.
  • Varga G; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
  • Kuzikov M; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Zaliani A; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Rahighi S; Chapman University School of Pharmacy (CUSP), Harry and Diane Rinker Health Science Campus, Chapman University, Irvine, CA 92618, USA.
  • Schaeffer V; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany.
  • Parnham MJ; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
  • Sidhu SS; The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Ernst A; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
  • Dötsch V; Institute of Biophysical Chemistry & Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main, Germany.
  • Akutsu M; Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany.
  • Dikic I; Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences,
Cell Chem Biol ; 27(11): 1441-1451.e7, 2020 11 19.
Article in En | MEDLINE | ID: mdl-32726587
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Full text: 1 Database: MEDLINE Main subject: Biological Products / Protein Engineering / NF-kappa B / Ubiquitin / Drug Discovery Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Cell Chem Biol Year: 2020 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Biological Products / Protein Engineering / NF-kappa B / Ubiquitin / Drug Discovery Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Cell Chem Biol Year: 2020 Type: Article