Antifibrotic effect of curcumin, N-acetyl cysteine and propolis extract against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment.
Life Sci
; 260: 118245, 2020 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-32791144
ABSTRACT
AIMS:
Bisphenol A (BPA) has been shown to induce liver fibrosis in rodents. Therefore, this study examined the protective effect of a triple combination of curcumin (Cur), N-acetyl cysteine (NAC) and propolis (Prp) extract against BPA-induced hepatic fibrosis.METHODS:
100 Wistar male rats were equally assigned into 10 groups; one group was designated as control. 10 rats were gavaged with BPA (50â¯mg/kg/day) for 8 wk and left un-treated (BPA group). The remaining 80 rats were divided into 8 groups, distributed in 2 models. Protective model rats were daily co-treated with BPA and Cur (100â¯mg/kg, p.o) or NAC (150â¯mg/kg, p.o) or Prp (200â¯mg/kg, p.o) or their combination for 8 wk. Preventive model rats were daily treated with Cur or NAC or Prp or their combination for 4 wk before BPA administration and then in the same manner as protective model. KEYFINDINGS:
Current treatment interventions significantly alleviated BPA-induced hepatic damage and fibrosis. They also restored pro-oxidant/antioxidant balance, shifted cytokine balance towards the anti-inflammatory side, decreasing interleukin-1ß/interleukin-10 ratio. Moreover, these compounds seem to exert anti-apoptotic effects by increasing the immunoexpression of B-cell lymphoma 2 in hepatocytes and decreasing hepatic caspase-3 content. Finally, they ameliorated extracellular matrix turn over through down-regulation of matrix metalloproteinase-9 and up-regulation of tissue inhibitor of matrix metalloproteinase-2 genetic expression.SIGNIFICANCE:
Current treatments guarded against BPA-induced hepatic fibrosis due to their antioxidant, anti-inflammatory and anti-apoptotic properties, decreasing extracellular matrix turnover. Interestingly, the triple therapy provided hepatoprotection superior to monotherapy. Besides, prophylactic and concurrent treatments seem to be more effective than concurrent treatments.Key words
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Apiterapia
/
Aromoterapia
/
Plantas_medicinales
Main subject:
Phenols
/
Propolis
/
Acetylcysteine
/
Benzhydryl Compounds
/
Curcumin
/
Liver Cirrhosis
Type of study:
Etiology_studies
/
Prognostic_studies
Language:
En
Journal:
Life Sci
Year:
2020
Type:
Article
Affiliation country:
Egypt