Synergistic antitumor activity of DHA and JQ1 in colorectal carcinoma.

Ding, Wanjing; Zhang, Haojian; Mei, Guangming

Ding, Wanjing; Zhang, Haojian; Mei, Guangming.

Affiliation

Ding W; Institute of Marine Biology& Pharmacology, Ocean College, Zhejiang University, Zhoushan, Zhejiang, 316021, China. Electronic address: wading@zju.edu.cn.
Zhang H; Institute of Marine Biology& Pharmacology, Ocean College, Zhejiang University, Zhoushan, Zhejiang, 316021, China.
Mei G; Marine Fishery Research Institute of Zhejiang Province, Zhoushan, Zhejiang, 316021, China.

Eur J Pharmacol ; 885: 173500, 2020 Oct 15.

Article in En | MEDLINE | ID: mdl-32861663

Subject(s)

Antineoplastic Agents/therapeutic use; Azepines/therapeutic use; Colorectal Neoplasms/drug therapy; Docosahexaenoic Acids/therapeutic use; Triazoles/therapeutic use; Animals; Apoptosis/drug effects; Cell Cycle Proteins/antagonists & inhibitors; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Synergism; Gene Expression Regulation, Neoplastic/drug effects; Humans; Mice; NF-kappa B/drug effects; Proto-Oncogene Proteins c-myc/antagonists & inhibitors; Transcription Factors/antagonists & inhibitors; Xenograft Model Antitumor Assays

Key words

Colon cancer; Docosahexaenoic acid (DHA); Drug combination; JQ1

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Azepines / Triazoles / Colorectal Neoplasms / Docosahexaenoic Acids / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Eur J Pharmacol Year: 2020 Type: Article

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