DNA-RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing.

Hara, Rintaro Iwata; Yoshioka, Kotaro; Yokota, Takanori

Hara, Rintaro Iwata; Yoshioka, Kotaro; Yokota, Takanori.

Affiliation

Hara RI; Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshioka K; Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Yokota T; Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. tak-yokota.nuro@tmd.ac.jp.

Methods Mol Biol ; 2176: 113-119, 2020.

Article in En | MEDLINE | ID: mdl-32865786

Subject(s)

Gene Silencing/drug effects; Nucleic Acid Heteroduplexes/pharmacology; Oligonucleotides, Antisense/pharmacology; RNA/pharmacology; Animals; Apolipoproteins B/genetics; Apolipoproteins B/metabolism; Genetic Therapy/methods; Humans; Liver/drug effects; Liver/metabolism; Nucleic Acid Heteroduplexes/chemistry; Nucleic Acid Heteroduplexes/therapeutic use; Oligonucleotides, Antisense/chemistry; Oligonucleotides, Antisense/therapeutic use; RNA/chemistry; RNA/therapeutic use

Key words

Antisense oligonucleotide (ASO); Drug delivery system (DDS); Heteroduplex oligonucleotide (HDO); Nucleic acid drug

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: RNA / Oligonucleotides, Antisense / Gene Silencing / Nucleic Acid Heteroduplexes Language: En Journal: Methods Mol Biol Year: 2020 Type: Article Affiliation country: Japan

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google