A novel fumarate, isosorbide di-(methyl fumarate) (IDMF), replicates astrocyte transcriptome responses to dimethyl fumarate (DMF) but specifically down-regulates genes linked to a reactive phenotype.

Swindell, William R; Bojanowski, Krzysztof; Chaudhuri, Ratan K

Swindell, William R; Bojanowski, Krzysztof; Chaudhuri, Ratan K.

Affiliation

Swindell WR; The Jewish Hospital, Department of Internal Medicine, Cincinnati, OH, 45236, USA. Electronic address: ws277814@ohio.edu.
Bojanowski K; Sunny BioDiscovery Inc., Santa Paula, CA, 93060, USA; Symbionyx Pharmaceuticals Inc., Boonton, NJ, 07005, USA. Electronic address: kbojanowski@sunnybiodiscovery.com.
Chaudhuri RK; Symbionyx Pharmaceuticals Inc., Boonton, NJ, 07005, USA; Sytheon Ltd., Boonton, NJ, 07005, USA. Electronic address: ratan@sytheonltd.com.

Biochem Biophys Res Commun ; 532(3): 475-481, 2020 11 12.

Article in En | MEDLINE | ID: mdl-32892947

Subject(s)

Astrocytes/drug effects; Dimethyl Fumarate/analogs & derivatives; Astrocytes/metabolism; Cells, Cultured; Dimethyl Fumarate/pharmacology; Down-Regulation/drug effects; Drug Evaluation, Preclinical; Genetic Predisposition to Disease; Humans; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Matrix Metalloproteinase Inhibitors/pharmacology; Mitosis/drug effects; Mitosis/genetics; Multiple Sclerosis, Relapsing-Remitting/drug therapy; Multiple Sclerosis, Relapsing-Remitting/genetics; NF-kappa B/genetics; NF-kappa B/metabolism; Phenotype; Protein Biosynthesis/drug effects; Transcriptome/drug effects

Key words

Astrocyte; Dimethyl fumarate; Isosorbide di-(methyl fumarate); Multiple sclerosis; NF-kappaB; NRF-2; RNA-seq

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Full text: 1 Database: MEDLINE Main subject: Astrocytes / Dimethyl Fumarate Type of study: Prognostic_studies Language: En Journal: Biochem Biophys Res Commun Year: 2020 Type: Article

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