The Antihypertensive Effect of Quercetin in Young Spontaneously Hypertensive Rats; Role of Arachidonic Acid Metabolism.

Elbarbry, Fawzy; Abdelkawy, Khaled; Moshirian, Nicholas; Abdel-Megied, Ahmed M

Elbarbry, Fawzy; Abdelkawy, Khaled; Moshirian, Nicholas; Abdel-Megied, Ahmed M.

Affiliation

Elbarbry F; School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Abdelkawy K; College of Pharmacy, Kafrelsheikh University, Kafrelsheikh City, Egypt.
Moshirian N; School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Abdel-Megied AM; School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.

Int J Mol Sci ; 21(18)2020 Sep 08.

Article in En | MEDLINE | ID: mdl-32911626

Subject(s)

Arachidonic Acid/metabolism; Hypertension/physiopathology; Quercetin/pharmacology; Animals; Antihypertensive Agents/metabolism; Antihypertensive Agents/pharmacology; Arachidonic Acid/physiology; Blood Pressure/drug effects; Cytochrome P-450 CYP4A/metabolism; Cytochrome P-450 Enzyme System/metabolism; Epoxide Hydrolases/metabolism; Hydroxyeicosatetraenoic Acids/metabolism; Hypertension/drug therapy; Hypertension/metabolism; Kidney/metabolism; Kidney Cortex/metabolism; Male; Microsomes/metabolism; Quercetin/metabolism; Rats; Rats, Inbred SHR

Key words

20-HETE; EETs; arachidonic acid; hypertension; metabolism; quercetin; soluble epoxide hydrolase; spontaneously hypertensive rats

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Full text: 1 Database: MEDLINE Main subject: Quercetin / Arachidonic Acid / Hypertension Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: United States

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