Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model.

Nsengiyumva, Vianne; Krishna, Smriti M; Moran, Corey S; Moxon, Joseph V; Morton, Susan K; Clarke, Michael W; Seto, Sai-Wang; Golledge, Jonathan

Nsengiyumva, Vianne; Krishna, Smriti M; Moran, Corey S; Moxon, Joseph V; Morton, Susan K; Clarke, Michael W; Seto, Sai-Wang; Golledge, Jonathan.

Affiliation

Nsengiyumva V; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Krishna SM; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Moran CS; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Moxon JV; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Morton SK; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Clarke MW; Metabolomics Australia, Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
Seto SW; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
Golledge J; NICM Health Research Institute, Western Sydney University, Penrith, NSW 2571, Australia.

Clin Sci (Lond) ; 134(18): 2521-2534, 2020 09 30.

Article in En | MEDLINE | ID: mdl-32936248

Subject(s)

Aortic Aneurysm, Abdominal/drug therapy; Aortic Aneurysm, Abdominal/etiology; Aortic Rupture/drug therapy; Aortic Rupture/etiology; Cholecalciferol/therapeutic use; Dietary Supplements; Disease Progression; Vitamin D Deficiency/complications; Adaptor Proteins, Signal Transducing/metabolism; Angiotensin II; Animals; Aorta, Abdominal/drug effects; Aorta, Abdominal/metabolism; Aorta, Abdominal/pathology; Aorta, Abdominal/physiopathology; Aortic Aneurysm, Abdominal/physiopathology; Aortic Rupture/physiopathology; Apolipoproteins E/deficiency; Blood Pressure/drug effects; Caloric Restriction; Cholecalciferol/pharmacology; Disease Models, Animal; Gene Expression Regulation/drug effects; Humans; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/metabolism; Up-Regulation/drug effects; Vitamin D Deficiency/physiopathology

Key words

Abdominal aortic aneurysm; sclerostin; vitamin D

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Full text: 1 Database: MEDLINE Main subject: Aortic Rupture / Vitamin D Deficiency / Aortic Aneurysm, Abdominal / Cholecalciferol / Disease Progression / Dietary Supplements Language: En Journal: Clin Sci (Lond) Year: 2020 Type: Article Affiliation country: Australia

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