Inhaled H<sub>2</sub> or CO<sub>2</sub> Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model.

Kovács, Viktória; Remzso, Gábor; Tóth-Szuki, Valéria; Varga, Viktória; Németh, János; Domoki, Ferenc

Inhaled H₂ or CO₂ Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model.

Kovács, Viktória; Remzso, Gábor; Tóth-Szuki, Valéria; Varga, Viktória; Németh, János; Domoki, Ferenc.

Affiliation

Kovács V; Department of Physiology, University of Szeged Faculty of Medicine, H-6720 Szeged, Hungary.
Remzso G; Department of Physiology, University of Szeged Faculty of Medicine, H-6720 Szeged, Hungary.
Tóth-Szuki V; Department of Physiology, University of Szeged Faculty of Medicine, H-6720 Szeged, Hungary.
Varga V; Department of Physiology, University of Szeged Faculty of Medicine, H-6720 Szeged, Hungary.
Németh J; Department of Physiology, University of Szeged Faculty of Medicine, H-6720 Szeged, Hungary.
Domoki F; Department of Physiology, University of Szeged Faculty of Medicine, H-6720 Szeged, Hungary.

Int J Mol Sci ; 21(18)2020 Sep 16.

Article in En | MEDLINE | ID: mdl-32948011

Subject(s)

Asphyxia Neonatorum/therapy; Brain Damage, Chronic/prevention & control; Carbon Dioxide/therapeutic use; Hydrogen/therapeutic use; Hypothermia, Induced; Hypoxia-Ischemia, Brain/therapy; Neuroprotection/drug effects; Neuroprotective Agents/therapeutic use; Acidosis/blood; Acidosis/etiology; Acidosis/prevention & control; Administration, Inhalation; Animals; Animals, Newborn; Apoptosis Inducing Factor/biosynthesis; Apoptosis Inducing Factor/genetics; Asphyxia Neonatorum/complications; Asphyxia Neonatorum/drug therapy; Brain Damage, Chronic/etiology; Brain-Derived Neurotrophic Factor/biosynthesis; Brain-Derived Neurotrophic Factor/genetics; Carbon Dioxide/administration & dosage; Carbon Dioxide/toxicity; Caspase 3/biosynthesis; Caspase 3/genetics; Caudate Nucleus/pathology; Cerebral Cortex/metabolism; Cerebral Cortex/pathology; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Evoked Potentials, Visual/drug effects; Gene Expression Regulation/drug effects; Hippocampus/pathology; Hydrogen/administration & dosage; Hydrogen/analysis; Hypoxia-Ischemia, Brain/complications; Hypoxia-Ischemia, Brain/drug therapy; Hypoxia-Ischemia, Brain/pathology; Nerve Tissue Proteins/biosynthesis; Nerve Tissue Proteins/genetics; Neuroprotective Agents/administration & dosage; Organ Specificity; Random Allocation; Swine

Key words

brain-derived neurotrophic factor; hydrogen ventilation; hypoxic-ischemic encephalopathy; perinatal asphyxia; piglet model; therapeutic hypothermia

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Full text: 1 Database: MEDLINE Main subject: Asphyxia Neonatorum / Brain Damage, Chronic / Carbon Dioxide / Neuroprotective Agents / Hypoxia-Ischemia, Brain / Neuroprotection / Hydrogen / Hypothermia, Induced Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Hungary

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