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Longisglucinols A-C, Structurally Intriguing Polycyclic Polyprenylated Acylphloroglucinols with Anti-inflammatory Activity from Hypericum longistylum.
Zhang, Na; Shi, Zhengyi; Xu, Qianqian; Sun, Weiguang; Gu, Lianghu; Xie, Shuangshuang; Guo, Yi; Duan, Yulin; Zhang, Kailin; Qi, Changxing; Zhang, Yonghui.
Affiliation
  • Zhang N; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Shi Z; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Xu Q; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Sun W; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Gu L; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Xie S; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Guo Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Duan Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Zhang K; Hubei Hualong Bio-chemical Pharmaceutical Co., Ltd., Wuhan 430030, People's Republic of China.
  • Qi C; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • Zhang Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Org Lett ; 22(20): 7926-7929, 2020 10 16.
Article in En | MEDLINE | ID: mdl-33002355
ABSTRACT
Longisglucinol A (1), a polycyclic polyprenylated acylphloroglucinol (PPAP) with a new skeleton, along with two new congeners, longisglucinols B (2) and C (3), were isolated from Hypericum longistylum. Compound 1 features an unparalleled 6/6/6/5 fused ring skeleton based on a unique 8-oxa-tetracyclo-[8.3.3.01,9.03,7]cetane core. Longisglucinol A showed remarkable anti-inflammatory activity by inducing macrophage M2 polarization through the suppression of NF-κB.
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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: NF-kappa B / Hypericum / Anti-Inflammatory Agents Language: En Journal: Org Lett Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: NF-kappa B / Hypericum / Anti-Inflammatory Agents Language: En Journal: Org Lett Year: 2020 Type: Article