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Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation.
Wen, Yongjian; Han, Chenxia; Liu, Tingting; Wang, Rui; Cai, Wenhao; Yang, Jingyu; Liang, Ge; Yao, Linbo; Shi, Na; Fu, Xianghui; Deng, Lihui; Sutton, Robert; Windsor, John A; Hong, Jiwon; Phillips, Anthony R; Du, Dan; Huang, Wei; Xia, Qing.
Affiliation
  • Wen Y; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China; West China-Washington Mitochondria and Metabolism Center, West China Hospital
  • Han C; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Liu T; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang R; West China-Washington Mitochondria and Metabolism Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Cai W; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China; Liverpool Pancreatitis Study Group, Royal Liverpool University Hospital and I
  • Yang J; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Liang G; West China-Washington Mitochondria and Metabolism Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yao L; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Shi N; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Fu X; Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
  • Deng L; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Sutton R; Liverpool Pancreatitis Study Group, Royal Liverpool University Hospital and Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, United Kingdom.
  • Windsor JA; Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand.
  • Hong J; Applied Surgery and Metabolism Laboratory, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand; Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand.
  • Phillips AR; Applied Surgery and Metabolism Laboratory, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand; Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand.
  • Du D; West China-Washington Mitochondria and Metabolism Center, West China Hospital, Sichuan University, Chengdu 610041, China; Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610000, China. Electronic addres
  • Huang W; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China; Liverpool Pancreatitis Study Group, Royal Liverpool University Hospital and I
  • Xia Q; Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: xiaqing@medmail.com.cn.
Phytomedicine ; 79: 153328, 2020 Dec.
Article in En | MEDLINE | ID: mdl-33007730
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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Pancreatitis / Drugs, Chinese Herbal / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Type of study: Diagnostic_studies Language: En Journal: Phytomedicine Year: 2020 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Pancreatitis / Drugs, Chinese Herbal / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Type of study: Diagnostic_studies Language: En Journal: Phytomedicine Year: 2020 Type: Article