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Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
White, Phillip J; Lapworth, Amanda L; McGarrah, Robert W; Kwee, Lydia Coulter; Crown, Scott B; Ilkayeva, Olga; An, Jie; Carson, Matthew W; Christopher, Bridgette A; Ball, James R; Davies, Michael N; Kjalarsdottir, Lilja; George, Tabitha; Muehlbauer, Michael J; Bain, James R; Stevens, Robert D; Koves, Timothy R; Muoio, Deborah M; Brozinick, Joseph T; Gimeno, Ruth E; Brosnan, M Julia; Rolph, Timothy P; Kraus, William E; Shah, Svati H; Newgard, Christopher B.
Affiliation
  • White PJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA; Division of Endocrinology, Department of Medicine, Duke University
  • Lapworth AL; CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA.
  • McGarrah RW; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Kwee LC; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Crown SB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • An J; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Carson MW; Diabetes Therapeutic Area, Lilly Research Laboratories, a Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
  • Christopher BA; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Ball JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Davies MN; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Kjalarsdottir L; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • George T; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
  • Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Stevens RD; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Koves TR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Geriatrics, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Muoio DM; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA; Division of Endocrinology, Department of Medicine, Duke University
  • Brozinick JT; Diabetes Therapeutic Area, Lilly Research Laboratories, a Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
  • Gimeno RE; Diabetes Therapeutic Area, Lilly Research Laboratories, a Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
  • Brosnan MJ; CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA.
  • Rolph TP; CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA.
  • Kraus WE; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Shah SH; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  • Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA; Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA; Division of Endocrinology, Department of Medicine, Duke University
Cell Rep ; 33(6): 108375, 2020 11 10.
Article in En | MEDLINE | ID: mdl-33176135
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Full text: 1 Database: MEDLINE Main subject: Muscle, Skeletal / Glycine / Liver / Nitrogen / Obesity Language: En Journal: Cell Rep Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Muscle, Skeletal / Glycine / Liver / Nitrogen / Obesity Language: En Journal: Cell Rep Year: 2020 Type: Article