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Design, Synthesis, and Biological Evaluation of Linear Aliphatic Amine-Linked Triaryl Derivatives as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction with Promising Antitumor Effects In Vivo.
Guo, Jialin; Luo, Longlong; Wang, Zhihong; Hu, Naijing; Wang, Wei; Xie, Fei; Liang, Erguang; Yan, Xinlin; Xiao, Junhai; Li, Song.
Affiliation
  • Guo J; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Luo L; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyBeijing 100850, China.
  • Wang Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyBeijing 100850, China.
  • Hu N; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyBeijing 100850, China.
  • Wang W; The Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130021, China.
  • Xie F; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Liang E; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Yan X; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Xiao J; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Li S; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
J Med Chem ; 63(22): 13825-13850, 2020 11 25.
Article in En | MEDLINE | ID: mdl-33186040
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Full text: 1 Database: MEDLINE Main subject: Drug Design / Fatty Acids / B7-H1 Antigen / Programmed Cell Death 1 Receptor / Antineoplastic Agents Language: En Journal: J Med Chem Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Drug Design / Fatty Acids / B7-H1 Antigen / Programmed Cell Death 1 Receptor / Antineoplastic Agents Language: En Journal: J Med Chem Year: 2020 Type: Article Affiliation country: China