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Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice.
Matthews, Donald G; Caruso, Maya; Alcazar Magana, Armando; Wright, Kirsten M; Maier, Claudia S; Stevens, Jan F; Gray, Nora E; Quinn, Joseph F; Soumyanath, Amala.
Affiliation
  • Matthews DG; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
  • Caruso M; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
  • Alcazar Magana A; Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
  • Wright KM; Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
  • Maier CS; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
  • Stevens JF; Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
  • Gray NE; Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
  • Quinn JF; Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
  • Soumyanath A; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Nutrients ; 12(11)2020 Nov 13.
Article in En | MEDLINE | ID: mdl-33202902
Centella asiatica (CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA's ability to improve learning and memory. This study evaluated the contribution of CA's triterpenes (TT), widely considered its active compounds, and caffeoylquinic acids (CQA) to the cognitive effects of CA water extract (CAW) in 5XFAD mice, a model of Alzheimer's disease. 5XFAD mice were fed a control diet alone, or one containing 1% CAW or compound groups (TT, CQA, or TT + CQA) equivalent to their content in 1% CAW. Wild-type (WT) littermates received the control diet. Conditioned fear response (CFR) was evaluated after 4.5 weeks. Female 5XFAD controls showed no deficit in CFR compared to WT females, nor any effects from treatment. In males, CFR of 5XFAD controls was attenuated compared to WT littermates (p = 0.005). 5XFAD males receiving CQA or TT + CQA had significantly improved CFR (p < 0.05) compared to 5XFAD male controls. CFR did not differ between 5XFAD males receiving treatment diets and WT males. These data confirm a role for CQA in CAW's cognitive effects.
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Full text: 1 Database: MEDLINE Main subject: Quinic Acid / Triterpenes / Centella / Alzheimer Disease / Cognitive Dysfunction Language: En Journal: Nutrients Year: 2020 Type: Article Affiliation country: United States

Full text: 1 Database: MEDLINE Main subject: Quinic Acid / Triterpenes / Centella / Alzheimer Disease / Cognitive Dysfunction Language: En Journal: Nutrients Year: 2020 Type: Article Affiliation country: United States