ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.

Zhang, Xiaoxin; Dong, Yingchun; Zhao, Mengxiang; Ding, Liang; Yang, Xihu; Jing, Yue; Song, Yuxian; Chen, Sheng; Hu, Qingang; Ni, Yanhong

Zhang, Xiaoxin; Dong, Yingchun; Zhao, Mengxiang; Ding, Liang; Yang, Xihu; Jing, Yue; Song, Yuxian; Chen, Sheng; Hu, Qingang; Ni, Yanhong.

Affiliation

Zhang X; Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Dong Y; Department of Anesthesiology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.
Zhao M; Department of Oral & Maxillofacial Surgery Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Ding L; Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Yang X; Department of Oral & Maxillofacial Surgery Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Jing Y; Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Song Y; Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Chen S; Department of Oral Pathology, Nanjing Stomatological hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
Hu Q; Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.
Ni Y; Department of Oral & Maxillofacial Surgery Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing 210008, China.

Theranostics ; 10(26): 12044-12059, 2020.

Article in En | MEDLINE | ID: mdl-33204328

Subject(s)

CD18 Antigens/metabolism; Cancer-Associated Fibroblasts/metabolism; Mouth Neoplasms/pathology; NAD/metabolism; Squamous Cell Carcinoma of Head and Neck/pathology; Cell Line, Tumor; Cell Proliferation; Chemotherapy, Adjuvant/methods; Coculture Techniques; Computational Biology; Electron Transport Complex I/antagonists & inhibitors; Electron Transport Complex I/metabolism; Female; Follow-Up Studies; Humans; Male; Metformin/pharmacology; Metformin/therapeutic use; Middle Aged; Mitochondria/metabolism; Mouth Mucosa/cytology; Mouth Mucosa/pathology; Mouth Mucosa/surgery; Mouth Neoplasms/mortality; Mouth Neoplasms/therapy; Oxidation-Reduction/drug effects; Oxidative Phosphorylation/drug effects; Progression-Free Survival; Squamous Cell Carcinoma of Head and Neck/mortality; Squamous Cell Carcinoma of Head and Neck/therapy; Tumor Microenvironment/drug effects; Up-Regulation; Warburg Effect, Oncologic/drug effects; Xenograft Model Antitumor Assays

Key words

ITGB2; NADH; cancer associated fibroblasts; lactate; oral squamous cell carcinoma; oxidative phosphorylation system

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Full text: 1 Database: MEDLINE Main subject: Mouth Neoplasms / CD18 Antigens / Cancer-Associated Fibroblasts / Squamous Cell Carcinoma of Head and Neck / NAD Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Theranostics Year: 2020 Type: Article Affiliation country: China

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