Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by Inhibiting Expression of Pontin and Mutant p53.

Ahn, Yong Tae; Kim, Min Sung; Kim, Youn Sook; An, Won Gun

Ahn, Yong Tae; Kim, Min Sung; Kim, Youn Sook; An, Won Gun.

Affiliation

Ahn YT; Research Institute for Longevity and Well-Being, Pusan National University, Busan 46241, Korea.
Kim MS; Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Korea.
Kim YS; Gene & Cell Therapy Research Center for Vessel-Associated Diseases, Pusan National University, Yangsan 50612, Korea.
An WG; Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Korea.

Mar Drugs ; 18(11)2020 Nov 20.

Article in En | MEDLINE | ID: mdl-33233699

Subject(s)

ATPases Associated with Diverse Cellular Activities/metabolism; Antineoplastic Agents/pharmacology; Breast Neoplasms/drug therapy; Carrier Proteins/metabolism; DNA Helicases/metabolism; Neoplastic Stem Cells/drug effects; Tumor Suppressor Protein p53/metabolism; ATPases Associated with Diverse Cellular Activities/genetics; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Carrier Proteins/genetics; Cell Movement/drug effects; Cell Proliferation/drug effects; DNA Helicases/genetics; Female; Gene Expression Regulation, Neoplastic; Humans; Mutation; Nanog Homeobox Protein/genetics; Nanog Homeobox Protein/metabolism; Neoplasm Invasiveness; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Octamer Transcription Factor-3/genetics; Octamer Transcription Factor-3/metabolism; Tumor Suppressor Protein p53/genetics; Xanthophylls/pharmacology

Key words

BT20; Nanog; Oct4; T47D; astaxanthin; cancer stem cells; mutp53; pontin; siRNA

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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Breast Neoplasms / Carrier Proteins / Tumor Suppressor Protein p53 / DNA Helicases / ATPases Associated with Diverse Cellular Activities / Antineoplastic Agents Language: En Journal: Mar Drugs Year: 2020 Type: Article

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