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Combination Therapy to Treat Fungal Biofilm-Based Infections.
Tits, Jana; Cammue, Bruno P A; Thevissen, Karin.
Affiliation
  • Tits J; Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Leuven, Belgium.
  • Cammue BPA; Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Leuven, Belgium.
  • Thevissen K; Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Leuven, Belgium.
Int J Mol Sci ; 21(22)2020 Nov 23.
Article in En | MEDLINE | ID: mdl-33238622
An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera Candida, Aspergillus or Cryptococcus. Only a few antifungal drugs, including echinocandins and liposomal formulations of amphotericin B, are available to treat such biofilm-based fungal infections. This review discusses combination therapy as a novel antibiofilm strategy. More specifically, in vitro methods to discover new antibiofilm combinations will be discussed. Furthermore, an overview of the main modes of action of promising antibiofilm combination treatments will be provided as this knowledge may facilitate the optimization of existing antibiofilm combinations or the development of new ones with a similar mode of action.
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Biofilms / Drug Resistance, Fungal / Mycoses / Antifungal Agents Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Belgium

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Biofilms / Drug Resistance, Fungal / Mycoses / Antifungal Agents Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Belgium