Fucoidan mitigated diabetic nephropathy through the downregulation of PKC and modulation of NF-&#954;B signaling pathway: in vitro and in vivo investigations.

Xu, Jingge; Wang, Yan; Wang, Zhen; Guo, Lanping; Li, Xinpeng

Fucoidan mitigated diabetic nephropathy through the downregulation of PKC and modulation of NF-κB signaling pathway: in vitro and in vivo investigations.

Xu, Jingge; Wang, Yan; Wang, Zhen; Guo, Lanping; Li, Xinpeng.

Affiliation

Xu J; College of Pharmacy, Linyi University, Linyi, Shandong, China.
Wang Y; College of Pharmacy, Linyi University, Linyi, Shandong, China.
Wang Z; College of Pharmacy, Linyi University, Linyi, Shandong, China.
Guo L; National Resources Center of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Li X; National Resources Center of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Phytother Res ; 35(4): 2133-2144, 2021 Apr.

Article in En | MEDLINE | ID: mdl-33264813

Subject(s)

Anticoagulants/therapeutic use; Diabetes Mellitus, Experimental/complications; Diabetic Nephropathies/drug therapy; NF-kappa B/metabolism; Peptide Fragments/metabolism; Polysaccharides/therapeutic use; Protein Kinase C/metabolism; Animals; Anticoagulants/pharmacology; Diabetes Mellitus, Experimental/drug therapy; Diabetic Nephropathies/pathology; Down-Regulation; Male; Polysaccharides/pharmacology; Rats; Rats, Sprague-Dawley; Signal Transduction

Key words

Laminaria japonica polysaccharides; PKC/NF-κB; diabetic nephropathy; histopathological analysis

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Full text: 1 Database: MEDLINE Main subject: Peptide Fragments / Polysaccharides / Protein Kinase C / NF-kappa B / Diabetes Mellitus, Experimental / Diabetic Nephropathies / Anticoagulants Type of study: Prognostic_studies Language: En Journal: Phytother Res Year: 2021 Type: Article Affiliation country: China

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