Ester modification at the 3' end of anti-microRNA oligonucleotides increases potency of microRNA inhibition.

Pham, Kevin M; Suter, Scott R; Lu, Shannon S; Beal, Peter A

Pham, Kevin M; Suter, Scott R; Lu, Shannon S; Beal, Peter A.

Affiliation

Pham KM; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, United States.
Suter SR; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, United States.
Lu SS; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, United States.
Beal PA; Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, United States. Electronic address: pabeal@ucdavis.edu.

Bioorg Med Chem ; 29: 115894, 2021 01 01.

Article in En | MEDLINE | ID: mdl-33290908

Subject(s)

Argonaute Proteins/metabolism; Esters/chemistry; MicroRNAs/chemistry; Oligonucleotides, Antisense/chemistry; Oligonucleotides/chemistry; Triazoles/chemistry; Cell Line; Click Chemistry; Drug Evaluation, Preclinical; Exonucleases/metabolism; Humans; Molecular Docking Simulation; Phosphoric Diester Hydrolases/metabolism; Protein Conformation; Small Molecule Libraries/chemistry; Structure-Activity Relationship

Key words

Anti-microRNA; Argonaute2; Click chemistry; MicroRNA; Molecular docking; RNA interference

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Full text: 1 Database: MEDLINE Main subject: Oligonucleotides / Triazoles / Oligonucleotides, Antisense / MicroRNAs / Esters / Argonaute Proteins Language: En Journal: Bioorg Med Chem Year: 2021 Type: Article Affiliation country: United States

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