Vildagliptin, a dipeptidyl peptidase-4 inhibitor, reduces betel-nut induced carcinogenesis in female mice.

Nath, Moumita; Bhattacharjee, Kasturi; Choudhury, Yashmin

Nath, Moumita; Bhattacharjee, Kasturi; Choudhury, Yashmin.

Affiliation

Nath M; Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
Bhattacharjee K; Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
Choudhury Y; Department of Biotechnology, Assam University, Silchar 788011, Assam, India. Electronic address: yashminchoudhury@aus.ac.in.

Life Sci ; 266: 118870, 2021 Feb 01.

Article in En | MEDLINE | ID: mdl-33310040

Subject(s)

Areca/toxicity; Dipeptidyl-Peptidase IV Inhibitors/pharmacology; Liver Neoplasms, Experimental/prevention & control; Oxidative Stress/drug effects; Plant Extracts/toxicity; Vildagliptin/pharmacology; Animals; Carcinogenesis; Dyslipidemias/chemically induced; Dyslipidemias/pathology; Dyslipidemias/prevention & control; Female; Liver Neoplasms, Experimental/chemically induced; Liver Neoplasms, Experimental/pathology; Mice; Signal Transduction

Key words

AMPK signaling; Akt-mTOR; Betel-nut; Carcinogenesis; Drug repurposing; Vildagliptin

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Full text: 1 Database: MEDLINE Main subject: Areca / Plant Extracts / Oxidative Stress / Dipeptidyl-Peptidase IV Inhibitors / Vildagliptin / Liver Neoplasms, Experimental Language: En Journal: Life Sci Year: 2021 Type: Article Affiliation country: India

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