Effects of dibenzothiophene, a sulfur-containing heterocyclic aromatic hydrocarbon, and its alkylated congener, 2,4,7-trimethyldibenzothiophene, on placental trophoblast cell function.

Raez-Villanueva, Sergio; Perono, Genevieve A; Jamshed, Laiba; Thomas, Philippe J; Holloway, Alison C

Raez-Villanueva, Sergio; Perono, Genevieve A; Jamshed, Laiba; Thomas, Philippe J; Holloway, Alison C.

Affiliation

Raez-Villanueva S; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Perono GA; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Jamshed L; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Thomas PJ; Environment and Climate Change Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada.
Holloway AC; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.

J Appl Toxicol ; 41(9): 1367-1379, 2021 09.

Article in En | MEDLINE | ID: mdl-33314207

Subject(s)

Placenta/drug effects; Thiophenes/toxicity; Trophoblasts/drug effects; Alkylation; Angiopoietin-Like Protein 4/drug effects; Angiopoietin-Like Protein 4/genetics; Cell Line; Endocrine Disruptors/toxicity; Estradiol/metabolism; Female; Humans; Industry; Neovascularization, Physiologic/drug effects; Petroleum; Pregnancy; Prostaglandins F/metabolism; Thiophenes/chemistry; Vascular Endothelial Growth Factor A/drug effects; Vascular Endothelial Growth Factor A/genetics

Key words

angiogenesis; estradiol; petroleum; placental function; progesterone; reproductive toxicology; steroidogenesis; trophoblast; unconventional oil and gas (UOG) extraction

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Full text: 1 Database: MEDLINE Main subject: Placenta / Thiophenes / Trophoblasts Language: En Journal: J Appl Toxicol Year: 2021 Type: Article Affiliation country: Canada

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