Carotenoids in Cancer Metastasis-Status Quo and Outlook.

Koklesova, Lenka; Liskova, Alena; Samec, Marek; Zhai, Kevin; Abotaleb, Mariam; Ashrafizadeh, Milad; Brockmueller, Aranka; Shakibaei, Mehdi; Biringer, Kamil; Bugos, Ondrej; Najafi, Masoud; Golubnitschaja, Olga; Büsselberg, Dietrich; Kubatka, Peter

Koklesova, Lenka; Liskova, Alena; Samec, Marek; Zhai, Kevin; Abotaleb, Mariam; Ashrafizadeh, Milad; Brockmueller, Aranka; Shakibaei, Mehdi; Biringer, Kamil; Bugos, Ondrej; Najafi, Masoud; Golubnitschaja, Olga; Büsselberg, Dietrich; Kubatka, Peter.

Affiliation

Koklesova L; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
Liskova A; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
Samec M; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
Zhai K; Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, 24144 Doha, Qatar.
Abotaleb M; Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, 24144 Doha, Qatar.
Ashrafizadeh M; Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanli, Tuzla, 34956 Istanbul, Turkey.
Brockmueller A; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956 Istanbul, Turkey.
Shakibaei M; Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, D-80336 Munich, Germany.
Biringer K; Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, D-80336 Munich, Germany.
Bugos O; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
Najafi M; Lambda Life JSC., 85101 Bratislava, Slovakia.
Golubnitschaja O; Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran.
Büsselberg D; Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran.
Kubatka P; Predictive, Preventive, Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, 53127 Bonn, Germany.

Biomolecules ; 10(12)2020 12 10.

Article in En | MEDLINE | ID: mdl-33321708

Subject(s)

Antineoplastic Agents, Phytogenic/therapeutic use; Carotenoids/therapeutic use; Epithelial-Mesenchymal Transition/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Neoplasm Metastasis/drug therapy; Neoplasms/drug therapy; Antineoplastic Agents, Phytogenic/chemistry; Antineoplastic Agents, Phytogenic/classification; Carotenoids/chemistry; Carotenoids/classification; Chemotherapy, Adjuvant; Epithelial-Mesenchymal Transition/genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Machine Learning; Matrix Metalloproteinases/genetics; Matrix Metalloproteinases/metabolism; Neoplasm Invasiveness; Neoplasm Metastasis/genetics; Neoplasm Metastasis/pathology; Neoplasms/genetics; Neoplasms/metabolism; Neoplasms/pathology; Precision Medicine; Receptors, Urokinase Plasminogen Activator/genetics; Receptors, Urokinase Plasminogen Activator/metabolism; Signal Transduction; Tissue Inhibitor of Metalloproteinases/genetics; Tissue Inhibitor of Metalloproteinases/metabolism; Urokinase-Type Plasminogen Activator/genetics; Urokinase-Type Plasminogen Activator/metabolism

Key words

3P medicine; apocarotenoids; artificial intelligence; cancer; carotenes; carotenoids; epithelial-mesenchymal transition; individualized patient profiling; invasion; liquid biopsy; metastasis; migration; multi-level diagnostics; patient stratification; personalization of medical services; predictive diagnosis; targeted prevention; xanthophylls

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Full text: 1 Database: MEDLINE Main subject: Carotenoids / Gene Expression Regulation, Neoplastic / Epithelial-Mesenchymal Transition / Neoplasm Metastasis / Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Language: En Journal: Biomolecules Year: 2020 Type: Article Affiliation country: Slovakia

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