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The Immunomodulating Properties of Tiger Milk Medicinal Mushroom, Lignosus rhinocerus TM02® Cultivar (Agaricomycetes) and Its Associated Carbohydrate Composition.
Sum, Alvin Yap Chee; Li, Xiaojie; Yeng, Yeannie Yap Hui; Razif, Muhammad Fazril Mohamad; Jamil, Amira Hajirah Abd; Ting, Ng Szu; Seng, Tan Chon; Cheung, Peter Chi Keung; Fung, Shin-Yee.
Affiliation
  • Sum AYC; Medicinal Mushroom Research Group (MMRG), Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Li X; School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; Institute for Advanced Study, Shenzhen University, Shenzhen, P.R. China.
  • Yeng YYH; Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Bandar Saujana Putra, Selangor, Malaysia.
  • Razif MFM; Medicinal Mushroom Research Group (MMRG), Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Jamil AHA; Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
  • Ting NS; LiGNO Research Initiative Department, Ligno Biotech Sdn. Bhd., Balakong Jaya, Selangor, Malaysia.
  • Seng TC; LiGNO Research Initiative Department, Ligno Biotech Sdn. Bhd., Balakong Jaya, Selangor, Malaysia.
  • Cheung PCK; Department of Biology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
  • Fung SY; Medicinal Mushroom Research Group (MMRG), Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Center for Natural Products Research and Drug Discovery (CENAR), University of Malaya, Kuala Lumpur, Malaysia; University of Malaya Centre for Proteomics Res
Int J Med Mushrooms ; 22(8): 803-814, 2020.
Article in En | MEDLINE | ID: mdl-33389874
ABSTRACT
Natural compounds found in Lignosus rhinocerus like polysaccharides and polysaccharide-protein complexes have the capabilities to modulate the immune system. It possesses antitumor and anti-inflammatory properties and is commonly used in Southeast Asia and Southern China to alleviate illness. To investigate its immunomodulating properties, composition of polysaccharides and the expression of cytokines/chemokines from L. rhinocerus (TM02®) cultivar treated RAW 264.7 were explored. It was revealed, CWE contains linear polysaccharides with 1,4-linkages and rhinoprolycan fraction (HMW & MMW) possesses 1,4-Glcp and 1,6-Glcp backbone and branched chain (1,3,6-Glcp, 1,4,6-Glcp, 1,3,6-Glcp, 1,2,4,6-Glcp). Cytokines profile showed upregulation from CWE (IL-5 12.078 ± 1.225), HMW (IL-6 7.297 ± 0.338; TIMP-1 3.358 ± 0.200), MMW (IL-5 15.412 ± 5.823; TIMP-1 1.747 ± 0.053), and LMW (MIP-2 3.495 ± 0.416; TIMP-1 7.573 ± 0.088) and possible involvement of NF-κB and MAPK signaling pathway. Further in vivo studies are needed to fully understand the immunomodulatory effects of TM02®.
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Full text: 1 Database: MEDLINE Main subject: Polyporaceae / Polysaccharides / Anti-Inflammatory Agents Type of study: Risk_factors_studies Country/Region as subject: Asia Language: En Journal: Int J Med Mushrooms Year: 2020 Type: Article Affiliation country: Malaysia
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Full text: 1 Database: MEDLINE Main subject: Polyporaceae / Polysaccharides / Anti-Inflammatory Agents Type of study: Risk_factors_studies Country/Region as subject: Asia Language: En Journal: Int J Med Mushrooms Year: 2020 Type: Article Affiliation country: Malaysia