Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway.

Lee, Wonwoo; Lee, Chang Hyung; Lee, Jungkyu; Jeong, Yoonseon; Park, Jong-Hyung; Nam, In-Jeong; Lee, Doo Suk; Lee, Hyun Myung; Lee, Jaehyun; Yun, Nayoung; Song, Jisun; Choi, Sooyeon; Kim, Sunyoung

Lee, Wonwoo; Lee, Chang Hyung; Lee, Jungkyu; Jeong, Yoonseon; Park, Jong-Hyung; Nam, In-Jeong; Lee, Doo Suk; Lee, Hyun Myung; Lee, Jaehyun; Yun, Nayoung; Song, Jisun; Choi, Sooyeon; Kim, Sunyoung.

Affiliation

Lee W; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: wwlee@helixmith.com.
Lee CH; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: chlee@helixmith.com.
Lee J; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: jklee@helixmith.com.
Jeong Y; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: ysjeong@helixmith.com.
Park JH; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: vetjh@naver.com.
Nam IJ; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: ijnam@helixmith.com.
Lee DS; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: dslee@helixmith.com.
Lee HM; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: hmlee2@helixmith.com.
Lee J; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: jaehyunlee@helixmith.com.
Yun N; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: nyyun@helixmith.com.
Song J; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: Jisun.Song@helixmith.com.
Choi S; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: Sooyeon.Choi@helixmith.com.
Kim S; R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, 07794, South Korea. Electronic address: sk@helixmith.com.

J Ethnopharmacol ; 270: 113795, 2021 Apr 24.

Article in En | MEDLINE | ID: mdl-33421604

Subject(s)

Acute Lung Injury/drug therapy; Anti-Inflammatory Agents/pharmacology; Antioxidants/pharmacology; Heme Oxygenase-1/metabolism; Membrane Proteins/metabolism; NF-E2-Related Factor 2/metabolism; Plant Extracts/pharmacology; Signal Transduction/drug effects; Acute Lung Injury/chemically induced; Acute Lung Injury/metabolism; Animals; Anti-Inflammatory Agents/chemistry; Anti-Inflammatory Agents/therapeutic use; Antioxidants/chemistry; Antioxidants/therapeutic use; Cytokines/genetics; Cytokines/metabolism; Heme Oxygenase-1/genetics; Inflammation/chemically induced; Inflammation/drug therapy; Inflammation/metabolism; Lipopolysaccharides/toxicity; Male; Medicine, Korean Traditional; Membrane Proteins/genetics; Mice; Mice, Inbred C57BL; Oxidative Stress/drug effects; Plant Extracts/chemistry; Plant Extracts/therapeutic use; RAW 264.7 Cells; Reactive Oxygen Species/metabolism; Up-Regulation/drug effects

Key words

Acute respiratory distress syndrome; Dioscorea batatas; HO-1; Inflammation; Nrf2; Schizonepeta tenuifolia; TADIOS; Taraxacum officinale

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Plantas_medicinales Main subject: Plant Extracts / Signal Transduction / Heme Oxygenase-1 / NF-E2-Related Factor 2 / Acute Lung Injury / Membrane Proteins / Anti-Inflammatory Agents / Antioxidants Type of study: Prognostic_studies Language: En Journal: J Ethnopharmacol Year: 2021 Type: Article

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