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Cassane diterpenoid derivative induces apoptosis in IDH1 mutant glioma cells through the inhibition of glutaminase in vitro and in vivo.
Huang, Guo-Dong; Chen, Fan-Fan; Ma, Guo-Xu; Li, Wei-Ping; Zheng, Yue-Yang; Meng, Xiang-Bao; Li, Zong-Yang; Chen, Lei.
Affiliation
  • Huang GD; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China.
  • Chen FF; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China.
  • Ma GX; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
  • Li WP; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China.
  • Zheng YY; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China.
  • Meng XB; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China.
  • Li ZY; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China. Electronic address: nils_lee@email.szu.edu.cn.
  • Chen L; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen 518035, China. Electronic address: chenlei_winner@163.com.
Phytomedicine ; 82: 153434, 2021 Feb.
Article in En | MEDLINE | ID: mdl-33529962
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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Apoptosis / Glioblastoma / Diterpenes / Glutaminase / Isocitrate Dehydrogenase / Mutation Language: En Journal: Phytomedicine Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Apoptosis / Glioblastoma / Diterpenes / Glutaminase / Isocitrate Dehydrogenase / Mutation Language: En Journal: Phytomedicine Year: 2021 Type: Article Affiliation country: China