Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and <i>in vitro</i> studies.

Hermawan, Adam; Ikawati, Muthi; Jenie, Riris Istighfari; Khumaira, Annisa; Putri, Herwandhani; Nurhayati, Ika Putri; Angraini, Sonia Meta; Muflikhasari, Haruma Anggraini

Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies.

Hermawan, Adam; Ikawati, Muthi; Jenie, Riris Istighfari; Khumaira, Annisa; Putri, Herwandhani; Nurhayati, Ika Putri; Angraini, Sonia Meta; Muflikhasari, Haruma Anggraini.

Affiliation

Hermawan A; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Ikawati M; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Jenie RI; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Khumaira A; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Putri H; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Nurhayati IP; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Angraini SM; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Muflikhasari HA; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.

Saudi Pharm J ; 29(1): 12-26, 2021 Jan.

Article in En | MEDLINE | ID: mdl-33603536

Key words

BCSCs, Breast cancer stem cells; Bioinformatics; Breast cancer stem cells; CSC, Cancer stem cell; DAVID, Database for Annotation, Visualization, and Integrated Discovery; DTPs, Direct target proteins; DXR, Doxorubicin; EGF, Epidermal growth factor; EMT, Epithelial to mesenchymal transition; ERα; FITC, fluorescein isothiocyanate; GO, Gene ontology; ITPs, Indirect target proteins; KEGG, Kyoto Encyclopedia of Genes and Genomes; MET, Metformin; MFP, Mammosphere forming potential; NAR, Naringenin; NMPs, Naringenin-mediated proteins; Naringenin; P53; PE, phycoerythrin; PPI, Protein-protein interaction; PTTN, Potential target of naringenin in inhibition of BCSCs; ROS, Reactive oxygen species; Targeted therapy; q-RT PCR, Quantitative real-time polymerase chain reaction

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Saudi Pharm J Year: 2021 Type: Article Affiliation country: Indonesia

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