Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients.

Latil, Mathilde; Camelo, Serge; Veillet, Stanislas; Lafont, René; Dilda, Pierre J

Latil, Mathilde; Camelo, Serge; Veillet, Stanislas; Lafont, René; Dilda, Pierre J.

Affiliation

Latil M; Biophytis, Sorbonne Université - BC9, 4 Place Jussieu, 75005 Paris, France.
Camelo S; Biophytis, Sorbonne Université - BC9, 4 Place Jussieu, 75005 Paris, France.
Veillet S; Biophytis, Sorbonne Université - BC9, 4 Place Jussieu, 75005 Paris, France.
Lafont R; Biophytis, Sorbonne Université - BC9, 4 Place Jussieu, 75005 Paris, France; Sorbonne Université, CNRS - Institut de Biologie Paris Seine (BIOSIPE), 75005 Paris, France.
Dilda PJ; Biophytis, Sorbonne Université - BC9, 4 Place Jussieu, 75005 Paris, France. Electronic address: pierre.dilda@biophytis.com.

Drug Discov Today ; 26(5): 1311-1318, 2021 05.

Article in En | MEDLINE | ID: mdl-33609783

Subject(s)

COVID-19 Drug Treatment; Renin-Angiotensin System/drug effects; SARS-CoV-2/pathogenicity; Angiotensin Receptor Antagonists/therapeutic use; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Animals; COVID-19/metabolism; COVID-19/virology; Commelinaceae; Drug Development; Ecdysone/analogs & derivatives; Ecdysone/therapeutic use; Host-Pathogen Interactions; Humans; Plant Extracts/therapeutic use; Proto-Oncogene Mas; Proto-Oncogene Proteins/agonists; Proto-Oncogene Proteins/metabolism; Receptors, G-Protein-Coupled/agonists; Receptors, G-Protein-Coupled/metabolism; SARS-CoV-2/metabolism

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Renin-Angiotensin System / SARS-CoV-2 / COVID-19 Drug Treatment Language: En Journal: Drug Discov Today Year: 2021 Type: Article Affiliation country: France

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