Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1&#945; pathways in breast cancer.

Su, Qi; Wang, Jingjing; Wu, Qing; Ullah, Asmat; Ghauri, Mohsin Ahmad; Sarwar, Ammar; Chen, Li; Liu, Feng; Zhang, Yanmin

Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer.

Su, Qi; Wang, Jingjing; Wu, Qing; Ullah, Asmat; Ghauri, Mohsin Ahmad; Sarwar, Ammar; Chen, Li; Liu, Feng; Zhang, Yanmin.

Affiliation

Su Q; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Wang J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Wu Q; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Ullah A; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Ghauri MA; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Sarwar A; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Chen L; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, P.R. China.
Liu F; Shaanxi Institute of International Trade & Commerce, Xianyang 712046, P.R. China.
Zhang Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China. Electronic address: zhang2008@mail.xjtu.edu.cn.

Phytomedicine ; 84: 153503, 2021 Apr.

Article in En | MEDLINE | ID: mdl-33636580

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Benzophenanthridines/pharmacology; Breast Neoplasms/drug therapy; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Isoquinolines/pharmacology; Receptor, EphB4/metabolism; Animals; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Mice, Inbred BALB C; Receptor, EphB4/genetics; STAT3 Transcription Factor/metabolism; Tumor Hypoxia/drug effects; Xenograft Model Antitumor Assays

Key words

Breast cancer; Ephrin type-B receptor 4; Hypoxia inducible factor-1α; Sanguinarine; Signal transducer and activator of transcription-3

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Receptor, EphB4 / Hypoxia-Inducible Factor 1, alpha Subunit / Benzophenanthridines / Isoquinolines / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Language: En Journal: Phytomedicine Year: 2021 Type: Article

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