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Cystine supplementation rebalances the redox homeostasis of microenvironment in non-small cell lung cancer cells and reverses their resistance to docetaxel.
Li, Si-Jia; Cao, Bei; Lu, Zhen-Yao; Sun, Run-Bin; Guo, Su-Han; Xie, Yuan; Aa, Ji-Ye; Wang, Guang-Ji.
Affiliation
  • Li SJ; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Cao B; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
  • Lu ZY; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Sun RB; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Guo SH; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
  • Xie Y; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Aa JY; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Wang GJ; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China. jiyea@cpu.edu.cn.
Acta Pharmacol Sin ; 42(12): 2132-2143, 2021 Dec.
Article in En | MEDLINE | ID: mdl-33658706
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Cystine / Docetaxel / Homeostasis / Lung Neoplasms / Antineoplastic Agents Language: En Journal: Acta Pharmacol Sin Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Cystine / Docetaxel / Homeostasis / Lung Neoplasms / Antineoplastic Agents Language: En Journal: Acta Pharmacol Sin Year: 2021 Type: Article Affiliation country: China