Natural lactucopicrin alleviates importin-&#945;3-mediated NF-&#954;B activation in inflammated endothelial cells and improves sepsis in mice.

Weng, Hui; He, Luanying; Liu, Xiuping; Li, Qing; Du, Yushi; Zheng, Jiakun; Wang, Dongliang

Natural lactucopicrin alleviates importin-α3-mediated NF-κB activation in inflammated endothelial cells and improves sepsis in mice.

Weng, Hui; He, Luanying; Liu, Xiuping; Li, Qing; Du, Yushi; Zheng, Jiakun; Wang, Dongliang.

Affiliation

Weng H; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China.
He L; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China.
Liu X; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China.
Li Q; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China.
Du Y; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China.
Zheng J; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China.
Wang D; Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Food, Nutrition and Health, Guangzhou 510080, China; Guangdong Engineering Technology Research Center for Nutrition Translation, Guangzhou 5100

Biochem Pharmacol ; 186: 114501, 2021 04.

Article in En | MEDLINE | ID: mdl-33684389

Subject(s)

Endothelial Cells/metabolism; Lactones/therapeutic use; NF-kappa B/metabolism; Sepsis/drug therapy; Sepsis/metabolism; Sesquiterpenes/therapeutic use; alpha Karyopherins/metabolism; Animals; Dose-Response Relationship, Drug; Endothelial Cells/drug effects; HL-60 Cells; Humans; Inflammation/chemically induced; Inflammation/drug therapy; Inflammation/metabolism; Lactones/pharmacology; Male; Mice; Mice, Inbred C57BL; Sepsis/chemically induced; Sesquiterpenes/pharmacology; alpha Karyopherins/antagonists & inhibitors

Key words

Endothelium; Importin-α3; Lactucopicrin; NF-κB; Sepsis

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Sesquiterpenes / NF-kappa B / Sepsis / Alpha Karyopherins / Endothelial Cells / Lactones Language: En Journal: Biochem Pharmacol Year: 2021 Type: Article Affiliation country: China

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