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Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections.
Xu, Hang; Yan, Zhong-Zuo; Guo, Meng-Bi; An, Ran; Wang, Xin; Zhang, Rui; Mou, Yan-Hua; Hou, Zhuang; Guo, Chun.
Affiliation
  • Xu H; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China.
  • Yan ZZ; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China.
  • Guo MB; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China.
  • An R; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China.
  • Wang X; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China.
  • Zhang R; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China.
  • Mou YH; School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Hou Z; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China. Electronic address: houzhuang8@sina.com.
  • Guo C; Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 China. Electronic address: chunguo@syphu.edu.cn.
Eur J Med Chem ; 216: 113337, 2021 Apr 15.
Article in En | MEDLINE | ID: mdl-33713977
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Selenium / Sterol 14-Demethylase / 14-alpha Demethylase Inhibitors / Miconazole / Antifungal Agents Language: En Journal: Eur J Med Chem Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Selenium / Sterol 14-Demethylase / 14-alpha Demethylase Inhibitors / Miconazole / Antifungal Agents Language: En Journal: Eur J Med Chem Year: 2021 Type: Article