<i>Zanthoxylum bungeanum</i> Seed Oil Elicits Autophagy and Apoptosis in Human Laryngeal Tumor Cells via PI3K/AKT/mTOR Signaling Pathway.

Bai, Yun'e; Hou, Jing; Zhang, Xiao T; Gao, Jian P; Zhou, Jiang T

Zanthoxylum bungeanum Seed Oil Elicits Autophagy and Apoptosis in Human Laryngeal Tumor Cells via PI3K/AKT/mTOR Signaling Pathway.

Bai, Yun'e; Hou, Jing; Zhang, Xiao T; Gao, Jian P; Zhou, Jiang T.

Affiliation

Bai Y; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi Province, China.
Hou J; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi Province, China.
Zhang XT; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi Province, China.
Gao JP; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi Province, China.
Zhou JT; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi Province, China.

Anticancer Agents Med Chem ; 21(18): 2610-2619, 2021.

Article in En | MEDLINE | ID: mdl-33797380

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Laryngeal Neoplasms/drug therapy; Plant Extracts/pharmacology; Plant Oils/pharmacology; Zanthoxylum/chemistry; Antineoplastic Agents, Phytogenic/chemistry; Antineoplastic Agents, Phytogenic/isolation & purification; Cell Proliferation/drug effects; Cell Survival/drug effects; Cells, Cultured; Drug Screening Assays, Antitumor; Humans; Laryngeal Neoplasms/metabolism; Laryngeal Neoplasms/pathology; Phosphatidylinositol 3-Kinases/metabolism; Plant Extracts/chemistry; Plant Extracts/isolation & purification; Plant Oils/chemistry; Plant Oils/isolation & purification; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Seeds/chemistry; Signal Transduction/drug effects; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/metabolism

Key words

PI3K/AKT/mTOR signaling pathway; Zanthoxylum bungeanum seed oil; apoptosis; autophagy; herbal medicine.; laryngeal cancer cell

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Full text: 1 Database: MEDLINE Main subject: Plant Oils / Plant Extracts / Laryngeal Neoplasms / Apoptosis / Zanthoxylum / Antineoplastic Agents, Phytogenic Language: En Journal: Anticancer Agents Med Chem Year: 2021 Type: Article Affiliation country: China

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