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Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor.
Rao, Danni; Li, Heng; Ren, Xuelian; Sun, Yaoliang; Wen, Cuiyun; Zheng, Mingyue; Huang, He; Tang, Wei; Xu, Shilin.
Affiliation
  • Rao D; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, 19 Yuquan Road, Beijing, 110039, China.
  • Li H; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Ren X; Center for Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Sun Y; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zu Chong Zhi Road, Shanghai, 201203, China.
  • Wen C; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zu Chong Zhi Road, Shanghai, 201203, China.
  • Zheng M; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Science, 19 Yuquan Road, Beijing, 110039, China.
  • Huang H; Center for Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Science, 19 Yuquan Road, Beijing, 110039, China.
  • Tang W; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Science, 19 Yuquan Road, Beijing, 110039, China. Electronic address: tangwei@simm.ac.cn.
  • Xu S; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, 19 Yuquan Road, Beijing, 110039, China. Electronic address: slxu@simm.ac.cn.
Eur J Med Chem ; 219: 113393, 2021 Jul 05.
Article in En | MEDLINE | ID: mdl-33845236
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase Inhibitors / ZAP-70 Protein-Tyrosine Kinase Language: En Journal: Eur J Med Chem Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase Inhibitors / ZAP-70 Protein-Tyrosine Kinase Language: En Journal: Eur J Med Chem Year: 2021 Type: Article Affiliation country: China